Enhancing cancer vaccine efficacy via modulation of the tumor microenvironment.
نویسنده
چکیده
The development of therapeutic cancer vaccines is impacted by immunosuppressive elements in the tumor microenvironment. Most immunogenic cancer proteins are "self," therefore, peripheral tolerance contributes substantially to tumor immune escape. Transforming growth factor beta (TGFbeta) actively modulates both inflammation and tolerance induction. Combining vaccination with agents that disarm TGFbeta will enhance vaccine efficacy.
منابع مشابه
CCR Translations Enhancing Cancer Vaccine Efficacy via Modulation of the Tumor Microenvironment
The development of therapeutic cancer vaccines is impacted by immunosuppressive elements in the tumor microenvironment. Most immunogenic cancer proteins are “self,” therefore, peripheral tolerance contributes substantially to tumor immune escape. Transforminggrowth factorβ (TGFβ) activelymodulatesboth inflammationand tolerance induction. Combining vaccination with agents that disarm TGFβ will e...
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ورودعنوان ژورنال:
- Clinical cancer research : an official journal of the American Association for Cancer Research
دوره 15 21 شماره
صفحات -
تاریخ انتشار 2009